Endocrine Abstracts

Introduction: Dopamine agonists, mainly cabergoline and bromocriptine, represent the first-line treatment option in the management of prolactinomas. They allow prolactin normalization and tumor shrinkage. However, a subset of individuals with macroprolactinoma could exhibit a varying degree of resistance to dopamine agonists. The aim of this study was to determine the prevalence of dopamine agonist-resistance in patients with macroprolactinoma and to assess its predictive fact...

Introduction: The diagnosis of primary hyperparathyroidism and hypoparathyroidism is still challenging because of the increasing frequency of non-classical presentations. The calcium-to-phosphorus ratio (Ca/P) (CPR) is an inexpensive biochemical marker that could be useful to diagnose parathyroid disorders.Aim: The aim of this study was to assess the performances of CPR in the diagnosis of primary hyperparathyroidism and hypoparathyroidism.<p class="...

Introduction: Primary hyperparathyroidism is a common endocrine disease. Its association with inflammatory and thrombotic events was rarely reported in the literature. The pathophysiological mechanisms of this association remain uncertain. Herein, we report a case of hypercalcemia secondary to primary hyperparathyroidism revealed by a deep vein thrombosis.Observation: A 65-year-old patient was referred to our department for primary hyperparathyroidism. T...

Introduction: Polyuria-polydipsia syndrome (PUPDS) requires a comprehensive diagnostic approach as it can reveal serious medical conditions. We report the case of a patient consulting for PUPDS related to a primary potomania. Case presentation: A 41-year-old patient with a history of multiple psychostimulants use was admitted for acute PUPDS after emotional shock and paucisymptomatic SARS-CoV-2 infection. Diuresis was estimated at 6 liters per 24 hours. ...

Introduction: Pituitary stalk interruption syndrome (PSIS) is a rare congenital pituitary defect with an estimated incidence of 0.5 per 100,00 births. This syndrome has heterogeneous clinical presentations with varying degrees of pituitary hormones deficiencies. PSIS is commonly diagnosed during neonatal period and infancy. However, when symptoms are not evident or overlooked, the diagnosis could be delayed exposing the patient to acute, such as acute adrenal insufficiency, an...